Discoidin Domain Receptors

Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX.

Also Known As:

DDR Proteins; Discoidin Domain Receptor; Proteins, DDR; Receptor, Discoidin Domain; Receptors, Discoidin Domain

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein-Tyrosine Kinases: 7697
        Receptor Protein-Tyrosine Kinases: 5999
        Discoidin Domain Receptors: 140
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Receptor Protein-Tyrosine Kinases: 5999
        Discoidin Domain Receptors: 140
      - Collagen Receptors: 294
        Discoidin Domain Receptors: 140
      - Immunologic Receptors: 9
        Mitogen Receptors: 76
        Discoidin Domain Receptors: 140
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7697
      - Receptor Protein-Tyrosine Kinases: 5999
        Discoidin Domain Receptors: 140

Lisa R Burger Selected Research

Lisa R Burger Research Topics

Disease

Drug/Important Bio-Agent (IBA)